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The River Misbourne rises in a field on the outskirts of Great Missenden in Buckinghamshire, passing through Little Missenden, Old Amersham, Chalfont St Giles, Chalfont St Peter and under the Chiltern railway line and the M25 motorway to its confluence with the River Colne just north of where the Colne is crossed by Western Avenue, the A40 road. It falls by around 310 feet in the course of its 17 mile length.

The name Misbourne is first attested, in the form Misseburne, in 1407.[1]:73 The -bourne element is agreed to derive from Old English burna (‘stream, river’), but the etymology of the first element is uncertain. It is thought to occur in the names of both Great and Little Missenden, and also in the Tring place-name Miswell. Frank Stenton and Allen Mawer guessed that it came from a hypothetical Anglo-Saxon personal name Myrsa, which they also supposed to be found in the name of Mursley.[2] Eilert Ekwall suggested that it came from a lost Old English word related to English moss, and to Danish mysse and Swedish missne (which denote plants of the genus Calla, such as water arum).[3] Recent researchers have tentatively preferred Ekwall’s guess, in which case the name Misbourne would once have meant something like ‘river where water-plants/marsh-plants grow’.[4][5]:54–55, 73

In 1906 the Great Western Railway (GWR) constructed the Chalfont Viaduct to carry trains between London and High Wycombe across the river. In the mid-1980s, when the M25 was being constructed, the Misbourne was diverted under the motorway via underground concrete culverts. The route of the motorway was then aligned to pass through the arches of the Chalfont Viaduct.[6][7]

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