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The River Thame /ˈteɪm/ is a river in Southern England. It is a tributary of the River Thames.

The general course of the River Thame is south-westward and it runs from each of the longest of its many sources to the River Thames about 40 mi (64 km). The Thame rises in the English county of Buckinghamshire and discharges in south-east Oxfordshire.

The Thame’s source is three streams which rise in the wide Vale of Aylesbury on the north side of the Chiltern Hills. These streams converge north-east of Aylesbury, the county town of Buckinghamshire. The Thame played a key role in the English Civil War when John Hampden (the town’s Member of Parliament) led the force of Parliamentarians successfully defending Aylesbury at the Battle of Holman’s Bridge, where a small road crosses the river, in 1642.

The vale streams converge by the 21st century small suburb of Watermead on the far side of a dug-out, flowing oxbow lake with several ornamental features (hence the name of the suburb). The suburb’s land was in the Middle Ages, the west of Bierton with Broughton parish and so is now in that civil parish. The Thame then passes farmland of the villages of Nether Winchendon and Chearsley before reaching the market town of Thame with which it shares its name. Thame is about 15 miles (24 km) east of Oxford and grew from an Anglo-Saxon settlement beside the river. In Anglo-Saxon England Thame is a recorded place in records of the Diocese of Dorchester.

At Holton mill the Thame turns quickly southward and after passing the villages of Great Milton and Stadhampton, its valley widens. In this area in 1642 and 1643, the river acted as a line of defence for Royalist Oxford. The bridges at Wheatley, Cuddesdon Mill and Chiselhampton were key crossing points, with Chiselhampton Bridge playing a critical part in Prince Rupert’s movements before and after the Battle of Chalgrove Field.[1]

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